Product ID:TETRACYCLINE, HYDROCHLORIDE, 58346
MSDS Date:12/21/1998
FSC:6505
NIIN:00N092494
Status Code:A
MSDS Number: CJTCF

Emergency Phone: 800-424-9300 (CHEMTREC)

Info Phone: 800-854-3417

Cage: 29089

Telephone: 619-450-5558; 800-854-3417

Cage: 29089

TETRACYCLINE, HYDROCHLORIDE

CAS: 64-75-5

RTECS: QI9100000

OSHA PEL N/K

ACGIH TLV: N/K

LD50 LC50 Mixture:SEE TOXICOLOGICAL INFORMATION.
Routes of Entry: Inhalation:YES Skin:YES Ingestion:YES
Reports of Carcinogenicity:NTP:NO IARC:NO OSHA:NO
Health Hazards Acute and Chronic:ACUTE: MAY BE HARMFUL BY INGESTION,
INHALATION OR ABSORPTION THROUGH SKIN. MATERIAL MAY CAUSE
IRRITATION. EXPOSURE TO MATERIAL MAY CAUSE THE FOLLOWING: FEVER,
PHOTOSENSITIVITY, ESOPHAGEAL OR GASTRIC B URNING, ABDOMINAL PAIN,
NAUSEA, VOMITING, DIARRHEA, INTRACRANIAL HYPERTENSION, HEMORRHAGE
OR SWELLING OF THE EYES, AND EXCESSIVE DEVELOPMENT OF THE MAMMARY
GLAND IN ANIMALS. CHRONIC: THERE IS LIMITED EVIDENCE THAT
TETRACYCLINE, HYDROCHLORIDE IS TERATOGENIC IN LABORATORY ANIMALS.
THERE IS ALSO LIMITED EVIDENCE THAT TETRACYCLINE, HYDROCHLORIDE IS
MUTAGENIC IN LABORATORY CELL CULTURES. (EFFECTS OF OV EREXPOSURE)
Effects of Overexposure:HEALTH HAZARDS: UNTIL FUTHER TESTING HAS BEEN
DONE, IT SHOULD BE TREATED AS A POSSIBLE TERATOGEN AND MUTAGEN IN
HUMANS.

First Aid:SKIN: WASH IMMEDIATELY WITH SOAP AND COPIOUS AMOUNTS OF WATER
FOR AT LEAST 15 MINUTES. REMOVE CONTAMINATED CLOTHING AND SHOES AND
WASH BEFORE WEARING. CONSULT A PHYSICIAN. EYES: FLUSH IMMEDIATELY
WITH COPIOUS AMOUNTS OF WATER FOR AT LEAST 15 MINUTES. ASSURE
ADEQUATE FLUSHING BY SEPARATING THE EYELIDS WITH FINGERS. CONSULT A
PHYSICIAN. INHALATION: REMOVE TO FRESH AIR AND MONITOR BREATHING.
IF BREAT HING BECOMES DIFFICULT, GIVE OXYGEN AND CONSULT A
PHYSICIAN. IF BREATHING STOPS, GIVE ARTIFICIAL RESPIRATION AND
CONSULT A PHYSICIAN. INGESTION: WASH MOUTH OUT WITH WATER AND
CONSULT THE LOCAL POISON CENTER AND A PHYSICIAN.

Extinguishing Media:DRY CHEMICAL POWDER, CARBON DIOXIDE, WATER SPRAY,
ALCOHOL OR POLYMER FOAM.
Fire Fighting Procedures:WEAR NIOSH APPROVED SCBA AND FULL PROTECTIVE
EQUIPMENT .
Unusual Fire/Explosion Hazard:UPON THERMAL DECOMPOSITION, IT MAY EMIT
TOXIC GASES.

Spill Release Procedures:EVACUATE AREA. WEAR A NIOSH APPROVED
SELF-CONTAINED BREATHING APPARATUS, RUBBER BOOTS, AND HEAVY RUBBER
GLOVES. SWEEP UP AND PLACE IN A SUITABLE CONTAINER. AVOID RAISING
DUST. HOLD FOR APPROPRIATE DIS POSAL. WASH SPILL SITE AND VENTILATE
AREA AFTER MATERIAL PICKUP IS COMPLETE.

Handling and Storage Precautions:STORE IN A TIGHTLY CLOSED CONTAINER IN
A COOL, DRY PLACE (+20C). POSSIBLE MUTAGEN. AVOID CONTACT WITH
MATERIAL. AVOID PROLONGED OR REPEATED EXPOSURE. LAB SHOULD BE
EQUIPPED WITH A SAFETY SHOWER AND AN EYE WASH STATION. WASH
THOROUGHLY AFTER HANDLING MATERIAL.
Other Precautions:MATERIAL SHOULD ONLY BE HANDLED BY QUALIFIED,
EXPERIENCED PROFESSIONALS.

Respiratory Protection:USE A NIOSH APPROVED RESPIRATOR.
Ventilation:HANDLE IN A CHEMICAL FUME HOOD WITH ADEQUATE VENTILATION.
Protective Gloves:CHEMICAL RESISTANT GLOVES.
Eye Protection:ANSI APPROVED CHEMICAL WORKERS GOGGLES .
Other Protective Equipment:ANSI APPROVED EMERGENCY EYEWASH AND DELUGE
SHOWER .
Work Hygienic Practices:WASH THOROUGHLY AFTER HANDLING.
Supplemental Safety and Health
SYNONYM: TETRACYCLINE, HYDROCHLORIDE. MOLECULAR WEIGHT: 480.9.
MOLECULAR FORMULA: C*22H*24N*2O*8 . CHL.

Melt/Freeze Pt:>220.C, 428.F
M.P/F.P Text:220C - 223C
Solubility in Water:SOLUBLE
Appearance and Odor:YELLOW SOLID.

Stability Indicator/Materials to Avoid:YES
AVOID CONTACT WITH STRONG OXIDIZING AGENTS. MATERIAL MAY DISCOLOR UPON
EXPOSURE TO LIGHT.
Stability Condition to Avoid:STABLE UNDER NORMAL HANDLING PROCEDURES.
Hazardous Decomposition Products:UPON THERMAL DECOMPOSITION, MAY EMIT
TOXIC GASES INCLUDING CARBON MONOXIDE, CARBON DIOXIDE, NITROGEN
OXIDES, AND HYDROGEN CHLORIDE GAS.

Waste Disposal Methods:COUNTRY, FEDERAL, STATE, & LOCAL REGULATIONS ARE
VARIED & CHANGE FREQUENTLY. FOR THIS REASON, MANUFACTURER
RECOMMENDS THAT YOU CONTACT YOUR LOCAL DEPARTMENT OF HEALTH
SERVICES FOR INFORMATION ON THE D ISPOSAL OF THIS PRODUCT/ARRANGE
FOR DISPOSAL BY A LICENSED DISPOSAL COMPANY. DISPOSE OF IN
ACCORDANC E WITH LOCAL, STATE, & FEDERAL REGULATIONS .

Toxicological Information:RTECS #: QI9100000. TOXICITY DATA &
REFERENCES: IPR; RAT; LD50: 318 MG/KG 1968. GENDAI NO RINSHO. 2,
26. IPR; MUS; LD50: 368 MG/KG 1964. JOURNAL OF PHARMACY &
PHARMACOLOGY. 16, 33. IVN; RAT; LD50: 128 MG/KG 1955. FARMACO,
EDIZIONE SCIENTIFICA. 10, 197. IVN; MUS; LD50: 157 MG/KG 1955.
FARMACO, EDIZIONE SCIENTIFICA. 10, 197. ORL; MAN; TDLO: 200
MG/KG/7D-1 CHANGE IN FUNC OF SENSE ORGANS 1985. CLINICA L PHARMACY.
4, 455. ORL; RAT; LD50: 6443 MG/KG 1971. TOXICOLOGY & APPLIED
PHARMACOLOGY. 18, 185. ORL; MUS; LD50: 2759 MG/KG 1964. JOURNAL OF
PHARMACY & PHARMACOLOGY. 16, 33. SCU; RAT; LD50: 700 MG/KG DIARR
1966. (ECOL INFO)

Disclaimer (provided with this information by the compiling agencies):
This information is formulated for use by elements of the Department
of Defense. The United States of America in no manner whatsoever,
expressly or implied, warrants this information to be accurate and
disclaims all liability for its use. Any person utilizing this
document should seek competent professional advice to verify and
assume responsibility for the suitability of this information to their
particular situation.

Ecological:NO INFORMATION AVAILABLE. --TOX INFO: TOXICOLOGY & APPLIED
PHARMACOLOGY. 9, 445. REPRO EFTS & REFERENCES: IPR; MUS; DOSE: 150
MG/KG MUSCULOSKELETAL SYS DEVEL ABNORMS 1972. IYAKUHIN KENKYU.
STUDY OF ME D SUPPLIES. 3, 82. ORL; RAT; DOSE: 14 GM/KG UROGENITAL
& MUSCULOSKELETAL SYS DEVEL ABNORMS 1965. TOXICOLOGY & APPLIED
PHARMACOLOGY. 7, 409. ORL; RAT; DOSE: 6 G/KG POST-IMPLANTATION
MORTALITY 1970. KIS O TO RINSHO. CLINICAL RPT. 4, 516. ORL; RBT;
DOSE: 9 G/KG POST-IMPLANTATION MORTALITY 1970. KISO TO RINSHO.
CLINICAL RPT. 4, 515. SCU; RAT; DOSE: 240 MG/KG TOX EFTS ON EMBRYO
1968. BIOCHEM PHARMACOLOG Y. 17, 1479. (SARA REGS)

Transport Information:UN NUMBER: N/A. PROPER SHIPPING NAME: N/A. IATA
CLASS: N/A. IATA PACKING GROUP: N/A.

SARA Title III Information:N/P. --ECOL INFO: GENETIC DATA & REFERENCES:
FBR; HMN; DOSE: 500 UMOL/L DNA DMG 1994. MUTATION RESEARCH. 315,
33. FBR; HMN; DOSE: 750 UMOL/L UNSCHEDULED DNA SYNTHESIS 1994.
MUTATION RESEARCH. 315, 33. FBR; HMN; DOSE: 1250 UMOL/L DNA
INHIBITION 1995. MUTATION RESEARCH. 348, 7. MAN; MUS; DOSE: 100
MG/L MUTATIONS IN MAMMALIAN SOMATIC CELLS 1976. MUTATION RESEARCH.
40, 261. MAN; MUS; DOSE: 31600 UG/L/ 24H CYTOGENETIC ANALYSIS 1976.
MUTATION RESEARCH. 40, 261. EMB; HAM; DOSE: 3 MG/L SISTER CHROMATID
EXCHANGE 1987. SISTER CHROMATID EXCHANGE 1987. SHIGAKU. ONDOTOLOGY.
74, 1385. MAN; MUS; DOSE: 31600 U G/L OTHER MUTATION TEST SYS
(STATE REGS)
Federal Regulatory Information:T. RISK PHRASES: R20/21/22: HARMFUL BY
INHALATION, IN CONTACT WITH SKIN AND IF SWALLOWED. R33: DANGER OF
CUMULATIVE EFFECTS. R36/37/38: IRRITATING TO EYES, RESPIRATORY
SYSTEM AND SKIN. R47: MAY CAUSE BIRTH DEFECTS. SAFETY PHRASES:
S22: DO NOT BREATHE DUST. S24/25: AVOID CONTACT WITH SKIN AND EYES.
S26: IN CASE OF CONTACT WITH EYES, RINSE IMMEDIATELY WITH PLENTY OF
WATER AND SEEK MEDICAL ADVICE. S3 6/37/39: WEAR SUITABLE PROTECTIVE
CLOTHING, GLOVES AND EYE/FACE PROTECTION. S45: IN CASE OF ACCIDENT
OR IF YOU FEEL UNWELL, SEEK MEDICAL ADVICE IMMEDIATELY. S53: AVOID
EXPOSURE - OBTAIN SPECIAL INSTRUCTIONS BEFORE USE.
State Regulatory Information:N/P. --SARA REGS: 1976. MUTATION RESEARCH.
40, 261. REFER TO THE REGISTRY OF TOXIC EFFECTS OF CHEMICAL
SUBSTANCES (RTECS) FOR A DEFINITION OF ABBREVIATIONS USED IN THE
ABOVE TEXT AND FOR ADDITIONAL IN FORMATION. THIS REPORT CONTAINS
ONLY SELECTED INFORMATION FROM THE RTECS.